The Dangers of Taking Suboxone During Pregnancy

pregnant woman taking suboxone during pregnancy

Even though the drug is shown to improve birth outcomes in newborns with opioid-addicted mothers, there are many dangers associated with taking Suboxone during pregnancy. Between 1999 and 2014, the number of women struggling with opioid use disorder who were delivering babies skyrocketed by more than 300%.[1] This number is startling, not only because of the ongoing opioid crisis but also because opioid abuse during pregnancy puts both the baby and the mother at high risk for complications. In lieu of this, studies have found that between 2000 and 2009, the number of babies who were born suffering from neonatal abstinence syndrome (NAS) tripled.[2]

NAS is a condition that occurs in babies who are born dependent on opioids as a result of their mother taking opioids during pregnancy. All opioids, including prescription painkillers and heroin, have the potential to pass through the placenta into the system of the unborn baby. As a result, these babies are born experiencing withdrawal symptoms – a condition that is known as neonatal opioid withdrawal syndrome (NOWS). Babies who experience neonatal abstinence syndrome (NAS) may suffer low birth weights, respiratory distress, seizures, fever, restlessness, trouble feeding, and be difficult or impossible to soothe.

In order to help ensure a safer birth for both the baby and the mother, physicians and addiction specialists often recommend Suboxone to their patients. Suboxone is known to help reduce cravings and help people refrain from using addictive opioids, like heroin, oxycodone, or fentanyl. However, Suboxone contains buprenorphine – which is an opioid drug in itself. As a result, anyone who is considering taking Suboxone during pregnancy needs to consult with their physician about the potential dangers and benefits. This knowledge helps ensure that a woman is making the best decision for herself and her baby.

When is Suboxone Used During Pregnancy?

Suboxone, a medication containing buprenorphine and naloxone, is a United States Food and Drug Administration (FDA) approved prescription drug used to treat opioid use disorder and opioid dependence. Buprenorphine, a partial opioid agonist, helps wean individuals off of stronger opioids over an extended period of time. This not only reduces the severity of withdrawal symptoms, but it also helps prevent drug cravings. As a result, Suboxone use combined with therapy in a medication-assisted treatment program is highly effective at lowering relapse rates and opioid-overdoses while improving birth outcomes in opioid-addicted mothers. It is often used in patients who are trying to come off of full agonist opioids, such as heroin, hydrocodone, or OxyContin.

Opioid withdrawal is characterized by troublesome flu-like symptoms that can be particularly harmful to an unborn baby. For example, experiencing opioid withdrawal with an unborn baby can lead to fetal distress, preterm labor, miscarriage, and other complications. In fact, opioid withdrawal can be potentially deadly to an unborn baby.

As a result, physicians and addiction specialists usually don’t recommend that pregnant women quit taking opioid drugs cold-turkey. Instead, they are weaned off of higher doses of opioids using medications like Suboxone or methadone.[3] However, it’s important to note that, because of the dangers of taking Suboxone or buprenorphine during pregnancy, most physicians prescribe single-action buprenorphine formulas rather than medications containing naloxone.

Complications Associated with Opioid Use During Pregnancy

There are many potential side effects of opioid abuse and dependence during pregnancy. Buprenorphine is not a strong or potent opioid, but when abused, may lead to similar birth defects and complications as opioids do. As a result, it is important to understand the side effects of taking Suboxone while pregnant. The CDC explains that

“…for mothers, opioid use disorder has been linked to maternal death; for babies, opioid use disorder or long-term opioid use has been linked to poor fetal growth, preterm birth, stillbirth, specific birth defects, and neonatal abstinence syndrome.”

Neonatal Opioid Withdrawal Syndrome

Overall, babies who are exposed to opioids while in the womb are more likely to have low birth weight, poor fetal growth, longer and more frequent hospital stays, be born premature, or experience birth defects.

Buprenorphine and Neonatal Abstinence Syndrome (NAS)

One primary concern regarding taking Suboxone during pregnancy is that buprenorphine may still lead to Neonatal abstinence syndrome. NAS refers to a group of problems that occur in newborns who were exposed to opioids for a long period of time while their mother was pregnant. Essentially, once the mother becomes dependent on opioids, the baby does, as well. If the mother is still using opioids a week or two before she gives birth, the baby will be born experiencing withdrawal symptoms. NAS may also occur in babies with mother’s addicted to alcohol, barbiturates, some antidepressants, and benzodiazepines.[4]

Since buprenorphine is a partial opioid, babies who are born to mothers who are taking the drug during pregnancy may experience NAS. Fortunately, the symptoms tend to be less severe in babies who are born dependent on buprenorphine versus babies who are born dependent on opioids. Similarly, their symptoms tend to last for shorter lengths of time. For example, NAS caused by buprenorphine may result in symptoms that begin 12-48 hours after birth, peak between 72-76 hours, and last approximately one week. However, there is some concern surrounding taking Suboxone during pregnancy because it contains Naloxone. For this reason, when buprenorphine is used during pregnancy it is usually prescribed in a single-action formula that contains only buprenorphine.

Possible Birth Defects Associated With Opioid Use

Other potential lasting side effects of taking an opioid or Suboxone during pregnancy include the risk of babies being born with a variety of different birth defects. According to the Centers for Disease Control and Prevention (CDC), the following are potential birth defects that may result if a mother abuses opioid or Suboxone while pregnant.

  • Glaucoma – a medical condition that causes damage to the optic nerve which may ultimately result in blindness
  • Spina bifida – a defect that occurs when the spinal cord does not develop properly. This can cause a variety of cognitive and physical disabilities
  • Hydrocephaly – refers to a build-up of spinal fluid in the brain which causes babies to be born with disproportionate heads. This condition can cause dangerous amounts of pressure in the brain.
  • Gastroschisis – a condition that causes a hole to form in the abdominal wall. As a result, a baby’s intestines may stick out or even protrude outside of the stomach.
  • Congenital heart defects – various conditions referring to abnormal function or structure of the heart that causes further heart problems and defects.

The label on Suboxone medications indicates the medication’s potential to cause harm to fetuses and unborn babies. As a result, pregnant women should only take Suboxone under the strict supervision of a medical professional while having full knowledge of the possible side effects of Suboxone during pregnancy.

Should Mothers Take Suboxone During Pregnancy?

There are many potential side effects of taking Suboxone while pregnant. First, naloxone may be dangerous to unborn babies because it is thought to cause hormonal changes in the mother and the fetus that may complicate the pregnancy. Furthermore, naloxone may precipitate worsening withdrawal symptoms in newborns, making it a significant risk. As a result, most physicians and treatment providers use single-action buprenorphine formulas when treating pregnant women who are suffering from opioid withdrawal rather than combination formulas like Suboxone.

Suboxone is considered a Category C drug – meaning studies have shown that the drug has adverse effects on the fetus, but the benefits may outweigh the potential risks.[5] Category C drugs are known for the potential to cause complications and congenital disabilities.

Still, other studies have suggested that Suboxone is a safer alternative to both opioids and many other opioid-replacement drugs like methadone.[6] In addition, women who are already taking Suboxone when they get pregnant are not generally told to stop taking it because it could spark acute withdrawal, putting the fetus at further risk. For this reason, it’s crucial to speak with your healthcare provider to determine which treatment method is best for you and your baby.

To learn more about Suboxone treatment or our addiction treatment programs in Memphis, contact us today.



Medically Reviewed: September 25, 2019

Dr Ashley

Medical Reviewer

Chief Editor


All of the information on this page has been reviewed and verified by a certified addiction professional.

Dr Ashley Murray obtained her MBBCh Cum Laude in 2016. She currently practices in the public domain in South Africa. She has an interest in medical writing and has a keen interest in evidence-based medicine.

All of the information on this page has been reviewed and verified by a certified addiction professional.